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The following term was not found in PubMed: 0942900
Page 1
Conserved Plasmodium Protein (PF3D7_0406000) of Unknown Function: In-silico Analysis and Cellular Localization.
Pandey I, Quadiri A, Wadi I, Pillai CR, Singh AP, Das A. Pandey I, et al. Infect Genet Evol. 2021 Aug;92:104848. doi: 10.1016/j.meegid.2021.104848. Epub 2021 Apr 3. Infect Genet Evol. 2021. PMID: 33823306
In spite of a decrease in malaria cases, the threat of malaria due to Plasmodium falciparum still prevails. The sequencing of Plasmodium falciparum reveals that approximately 60% of the Plasmodium genes code for hypothetical/putative proteins. ...Inter …
In spite of a decrease in malaria cases, the threat of malaria due to Plasmodium falciparum still prevails. The sequencing of Plas …
A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission.
Wichers-Misterek JS, Binder AM, Mesén-Ramírez P, Dorner LP, Safavi S, Fuchs G, Lenz TL, Bachmann A, Wilson D, Frischknecht F, Gilberger TW. Wichers-Misterek JS, et al. mBio. 2023 Feb 28;14(1):e0331822. doi: 10.1128/mbio.03318-22. Epub 2023 Jan 10. mBio. 2023. PMID: 36625655 Free PMC article.
Several MAPs have been identified in Toxoplasma gondii, and homologues can be found in the genomes of Plasmodium species, but the function of these proteins for asexual and sexual development of malaria parasites is still unknown. Here, we identified a …
Several MAPs have been identified in Toxoplasma gondii, and homologues can be found in the genomes of Plasmodium species, but the …
The acetylation of pknH is linked to the ethambutol resistance of Mycobacterium tuberculosis.
Sun Q, Zou Y, Feng Q, Gong Z, Song M, Li M, Chen Z. Sun Q, et al. Arch Microbiol. 2023 Sep 23;205(10):337. doi: 10.1007/s00203-023-03676-9. Arch Microbiol. 2023. PMID: 37740776
Escherichia coli, as the host of Mtb, was used for cloning and protein purification. Moreover, the immunoprecipitation was performed along with western blot to evaluate the EmbR phosphorylation and pknH acetylation. ...The EMB resistant (ER) Mtb strain showed faster …
Escherichia coli, as the host of Mtb, was used for cloning and protein purification. Moreover, the immunoprecipitation was performed …
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family.
Kundu P, Naskar D, McKie SJ, Dass S, Kanjee U, Introini V, Ferreira MU, Cicuta P, Duraisingh M, Deane JE, Rayner JC. Kundu P, et al. Nat Commun. 2023 Sep 14;14(1):5703. doi: 10.1038/s41467-023-40885-8. Nat Commun. 2023. PMID: 37709739 Free PMC article.
Using X-ray crystallography, we solved the structure of the PVP01_0000100 C-terminal tryptophan rich domain, which defines the TRAg family, revealing a three-helical bundle that is conserved across Plasmodium and has structural homology with lipid-binding BAR domain …
Using X-ray crystallography, we solved the structure of the PVP01_0000100 C-terminal tryptophan rich domain, which defines the TRAg family, …
The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites.
Loubens M, Marinach C, Paquereau CE, Hamada S, Hoareau-Coudert B, Akbar D, Franetich JF, Silvie O. Loubens M, et al. PLoS Pathog. 2023 Mar 16;19(3):e1011261. doi: 10.1371/journal.ppat.1011261. eCollection 2023 Mar. PLoS Pathog. 2023. PMID: 36928686 Free PMC article.
The claudin-like apicomplexan microneme protein (CLAMP) is a conserved protein that plays an essential role during invasion by Toxoplasma gondii tachyzoites and in Plasmodium falciparum asexual blood stages. ...Collectively, these results demonstrate t …
The claudin-like apicomplexan microneme protein (CLAMP) is a conserved protein that plays an essential role during inva …
Computational prediction and validation of specific EmbR binding site on PknH.
Na I, Dai H, Li H, Gupta A, Kreda D, Zhang P, Chen X, Zhang L, Alterovitz G. Na I, et al. Synth Syst Biotechnol. 2021 Nov 26;6(4):429-436. doi: 10.1016/j.synbio.2021.11.006. eCollection 2021 Dec. Synth Syst Biotechnol. 2021. PMID: 34901481 Free PMC article.
Genomic studies have shown that some genetic mutations in Mycobacterium tuberculosis (Mtb) EmbR, and EmbC/A/B genes cause EMB resistance. EmbR-PknH pair controls embC/A/B operon, which encodes EmbC/A/B genes, and EMB interacts with EmbA/B proteins. However, the EmbR …
Genomic studies have shown that some genetic mutations in Mycobacterium tuberculosis (Mtb) EmbR, and EmbC/A/B genes cause EMB resistance. Em …
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Molle V, Kremer L, Girard-Blanc C, Besra GS, Cozzone AJ, Prost JF. Molle V, et al. Biochemistry. 2003 Dec 30;42(51):15300-9. doi: 10.1021/bi035150b. Biochemistry. 2003. PMID: 14690440
Here we show that protein PknH possesses an autokinase activity and belongs to the large STPK family found in Mycobacterium tuberculosis. Evidence is presented that PknH can also phosphorylate EmbR, a protein suspected to modulate the level of arabinos …
Here we show that protein PknH possesses an autokinase activity and belongs to the large STPK family found in Mycobacterium tu …
Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase.
Zheng X, Papavinasasundaram KG, Av-Gay Y. Zheng X, et al. Biochem Biophys Res Commun. 2007 Mar 30;355(1):162-8. doi: 10.1016/j.bbrc.2007.01.122. Epub 2007 Jan 30. Biochem Biophys Res Commun. 2007. PMID: 17286964
PknH Ser/Thr protein kinase of Mycobacterium tuberculosis controls the expression of a variety of cell wall related enzymes and regulates the in vivo growth in mice. ...Unlike the EmbR protein, the Rv0681 and DacB1 proteins do not contain an FHA domain …
PknH Ser/Thr protein kinase of Mycobacterium tuberculosis controls the expression of a variety of cell wall related enzymes an …
Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference.
Mata E, Farrell D, Ma R, Uranga S, Gomez AB, Monzon M, Badiola J, Anel A, Gonzalo-Asensio J, Martin C, Gordon SV, Aguilo N. Mata E, et al. PLoS Pathog. 2020 Dec 21;16(12):e1009061. doi: 10.1371/journal.ppat.1009061. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33347499 Free PMC article.
Importantly, all the analysed M. bovis and M. caprae strains carry a conserved deletion within a proline rich-region of pknH, independent of the presence or absence of RD900. We hypothesized that deletion of pknH proline rich-region in M. bovis may affect …
Importantly, all the analysed M. bovis and M. caprae strains carry a conserved deletion within a proline rich-region of pknH, …
Extrachromosomal DNA in the Apicomplexa.
Wilson RJ, Williamson DH. Wilson RJ, et al. Microbiol Mol Biol Rev. 1997 Mar;61(1):1-16. doi: 10.1128/mmbr.61.1.1-16.1997. Microbiol Mol Biol Rev. 1997. PMID: 9106361 Free PMC article. Review.
Malaria and related apicomplexan parasites have two highly conserved organellar genomes: one is of plastid (pl) origin, and the other is mitochondrial (mt). ...The 35-kb circular DNA is the smallest known vestigial plastid genome and is presumed to be functional. Al …
Malaria and related apicomplexan parasites have two highly conserved organellar genomes: one is of plastid (pl) origin, and the other …
187 results